As said, the concept of “resistance” has been described also for the P2Y12 inhibitor clopidogrel, and it has been associated with both modifiable and non-modifiable risk factors, including T2DM, body mass index, age, gender, smoking, and genetic polymorphisms, such as insulin receptor substrate-1 polymorphisms [46]. This evidence concerns the gene P2RY12 and type 2 diabetes mellitus.