We selected two predicted SL partners of PIK3CA (Fig. 5), protein kinase PKN3 and the DNA binding transcription factor HMX3, which were consistently detected in both the Achilles 2.4 and COLT-cancer datasets with improved statistical significance after cleaning (Additional file 1: Figure S7; see “Methods” for details of the selection criteria). The gene discussed is HMX3; the disease is cancer.