Gene regions spanning the identified four-SNP signature, HLA-DQB2, MBP, UVRAG, and ZAK(CDCA7), are known to be related to either the MoA of Copaxone or the pathophysiology of multiple sclerosis (Additional file 10): HLA-DQB2 is involved in antigen processing and presentation, central to Copaxone’s MoA. This evidence concerns the gene MAP3K20 and multiple sclerosis.