A recent report suggested that nucleotide-binding domain, leucine-rich containing family, pyrin domain-containig-3 (Nlrp3) inflammasome plays a pivotal role in obesity-induced chronic inflammation, and Nlrp3 inflammasome activates caspase-1, which induces the secretion of IL-1β [24]. Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.