IL18 and dengue disease: To further examine the relationship between heightened biomarkers and the severity of dengue disease, we assessed the relationship of biomarkers that had shown to be significantly elevated in SD and DWS+ in both febrile phase (i.e. IL-18, LBP and sCD14) and defervescence phase (IL-18, CXCL6, IL-10 and IP-10) by using binary regression model controlling for age, gender and platelet counts.