Whether ataxin‐7, the mammalian orthologue of Sgf73, is similarly important for acetylation‐mediated regulation of transcription and how polyglutamine expansion of ataxin‐7 in the human neurological disorder SCA7 may alter this acetylation regulation to promote neurodegeneration are important questions for future studies. The gene discussed is ATXN7; the disease is spinocerebellar ataxia 7.