The TT variant of rs3830041 was associated with increased death risk in the following subgroups: age ≤45 years, nonsmoking status, AFP >400 ng/ml, cirrhosis, PVTT, antiviral therapy, nonadjuvant TACE, nonradical resection, nonregional invasion, nonintrahepatic metastasis, and vascular invasion. The gene discussed is AFP; the disease is Cirrhosis.