The rs422951 CC genotype was associated with increased risk of death in the following subgroups: age >45 years, smoking status, AFP >400 ng/mL, non‐PVTT, Child‐Pugh B, cirrhosis, BCLC stages B and C, nonadjuvant TACE, regional invasion, and intrahepatic metastasis. This evidence concerns the gene AFP and Cirrhosis.