Fabry disease (FD) is an X-linked lysosomal storage disease, characterized by deficient activity of the lysosomal enzyme alpha-galactosidase A (AGAL), which leads to globotriaosylceramide (Gb3) depositions in the lysosomes of various cell types and increased plasma globotriaosylsphingosine (lysoGb3) levels (Brady et al 1967, Aerts et al 2008). Here, GLA is linked to Fabry disease.