A further study on plastic mixtures by the same group revealed that the incidence of obesity and reproductive disorders, but not kidney and prostate diseases, was increased in the F3 generation and that changes in the differential methylation regions associated with obesity-related genes (namely, Tnfrsf12a, Esrra, Fgf19, Wnt10b, and Gdnf) were observed in the sperm of the F3 generation [200]. Here, ESRRA is linked to obesity due to melanocortin 4 receptor deficiency.