Here in our study, we aim to explore the effect of antiviral treatment of CHC patients with DAAs on the frequency of monocytes (classic CD14++CD16− monocytes and inflammatory CD14+CD16+ monocytes) [18], NK cells (CD3−CD16+CD56+) [19], and cytokines IL-12, IL-18, CXCL10, and CXCL11, which are necessary to activation of NK cells, and soluble CD14 (sCD14) and soluble CD163 (sCD163), which reflect monocytes activation. This evidence concerns the gene CD163 and cryohydrocytosis.