In conclusion, our results show that DAAs treatment attenuated the activation of monocytes and NK cells in CHC patients during DAAs treatment, indicated by decreased levels of sCD14, sCD163, IL-12, IL-18, CXCL10, and CXCL11 and normalization of the frequency of monocytes and NK cells, but the effect of DAAs treatment on their function still needs further research. This evidence concerns the gene IL18 and cryohydrocytosis.