KLK3 and prostate intraepithelial neoplasia: Patients with non-evanescent prostate carcinoma displayed clear histological signs of PIN (69%), considerable cancer aggressiveness (50% patients with a Gleason score of 8 and above), increased levels of PSA (83.5 ± 252.2), and showed clinical and pathological features of cancer progression (TNM stages: IIA to IV).