Next, we calculated percentage of coverage by CD105+ blood vessels and COX2+ cells in TLO-associated microenvironments and tumor areas with equal dimensions, as explained in Section “Materials and Methods.” The percentage of area covered by CD105+ vessels was approximately two times larger in TLO from PIN patients (0.43 ± 0.33%), compared with area occupied by CD105+ vessels in TLO from intermediate (0.2 ± 0.16%, p = 0.0102) and evanescent carcinoma patients (0.25 ± 0.11%, p = 0.0401) (Figure 6A). This evidence concerns the gene PTGS2 and prostate intraepithelial neoplasia.