Nevertheless, the risk-benefit of therapies in prostate cancer patients should be carefully assessed to decide whether induction of tissue damage is better than losing the invaluable opportunity for timely delivery of cell-based and/or COX2 blocking therapies to reverse tumor immune suppression, enhance tumor immunity in TLO, and prolong life expectancy of prostate cancer patients. The gene discussed is PTGS2; the disease is Familial prostate cancer.