In the context of cancer regression, reduction in TLO size correlated with massive decline in PSCA+ cells, enrichment in components associated with favorable tumor immunity (CD8 T cell accumulation, increase in HEV size), and the considerable reversion of local immunosuppression (notable reduction in COX2 cell density and Treg infiltration) and tumor neovascularization. The gene discussed is PTGS2; the disease is cancer.