CD8A and prostate intraepithelial neoplasia: Morphometric analysis revealed that CD8 T cells in TLO were significantly more abundant in PIN patients (56.45 ± 9.19), compared to numbers of CD8 T cells in TLO from intermediate (35.16 ± 8.53, p < 0.0001), advanced (20 ± 5.41, p < 0.0001), and evanescent prostate carcinoma (37.77 ± 10.61, p = 0.0005) (Figure 4A).