The chaperones Hsp90 and Hsp70 appear to interact with different molecules both in the cell membrane and extracellular matrix, like tissue transglutaminase (tTG), the tyrosine kinase receptor HER-2 and matrix metalloproteinase-2 (MMP-2) and these interactions are important to allow cancer cell migration. The gene discussed is NTRK1; the disease is cancer.