Interestingly, despite the important role of CD157 in the immune system (Shimaoka et al., 1998; Lo Buono, 2014), the CD157/BST1 gene was identified as a risk-factor for neurodegeneration, particularly for Parkinson's disease (PD), or at least one of a variety of PD symptoms (Satake et al., 2009; Simón-Sánchez et al., 2011; Sharma et al., 2012; Zhu et al., 2012; Liu et al., 2013b). This evidence concerns the gene BST1 and Parkinson disease.