In order to assess if our miRNA signature can offer some quantitative aspect, we further identified that some principal coordinate from the miRNA signature correlated with CRP values (R2 = 0.4239, P = 0.0574, Fig. 4A), highlighting that the identified miRNA signature can offer quantitative aspects, that can be used on an index scale, such as the CDAI (Crohn’s Disease Activity Index36). The gene discussed is CRP; the disease is Crohn disease.