TNF and colitis: No sign of hemolysis was detected in the samples as attested by dCq (miR-23a - miR-451) (Fig. S7B), and the unchanged expression levels of let-7d-3p mmu-miR-21a-5p, two miRNAs that were not identified as colitis-associated, ruled out the possibility of a global circulating miRNA reduction due to anti-TNFα therapy (Fig. S7C and D).