Moreover, it has been reported that a curcumin analogue ((1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-dione) down-regulated cyclin D1 and activated Caspase 3, 8 and 9 in lung adenocarcinoma (A549), leukemia (K562) and colon cancer (SW480) cells14. Here, CCND1 is linked to malignant colon neoplasm.