GSK3B and hepatocellular carcinoma: In this study, we examined the regulatory effect of GSK3β on HCV replication and virion production in the human hepatoma cell line (Huh7.5), and the potential interaction with VLDL assembly and Apo E and B. We used two GSK3 inhibitors: lithium (Li), a non-selective GSK3 inhibitor and an FDA-approved mood stabilizer, and AR-A014418 (AR), a small molecule heterocyclic thiazole compound that acts as a selective GSK3β inhibitor.