ABCG2 and gout: Examples of uncommon (1–2%), but not rare, genetic variants associated with gout are a coding variant in the ALDH16A1 gene in the Icelandic population (c.1580C > G; odds ratio, 3.7) [30], and the aforementioned knockout variant in the ABCG2 gene in the Japanese population (Q126X; odds ratio, 4.3) [24].