In combination with evidence that ABCG2 associates with gout using people with asymptomatic hyperuricemia as controls even after adjusting for baseline serum urate levels [44], it can be suggested that, in addition to its effects on serum urate, ABCG2 variants may influence other checkpoints in the pathogenesis of gout, such as crystal formation and/or the inflammatory response to deposited crystals. The gene discussed is ABCG2; the disease is hyperuricemia.