Compared with the asthma group, the asthma + miR-145 mimics and asthma + si-EGFR groups showed significantly elevated miR-145 expression, but simultaneously reduced expressions of EGFR, MUC5AC, TSLP, MMP-9, TIMP-1 and other cytokines (all P< 0.05) (Figure 5 and Table 3). The gene discussed is MUC5AC; the disease is asthma.