Accordingly, in the American registry,20 the mean TTR was 65%, with 17% of patients withINR below the therapeutic range, also showing a greater adherence to the guidelines.In the present study, although about 60% of patients used warfarin at the time ofinclusion and during follow-up, one-third of the patients had AF valvular and 20.5%had a history of previous embolism, with TTR lability being observed in 77, 1% ofthe patients, evidencing an inadequate adherence to the treatment. This evidence concerns the gene TTR and atrial fibrillation.