These data confirmed that TPD52 played an important role in CRC metastasis and was positively associated with celluar motility in SW480 cells.It has been shown that the PrLZ gene, encoding TPD52 or a member of TPD52 family, is reactivated and its expression is positively associated with cancer progression [41] and is able to activate PI3K/Akt signalling to regulate progression and development in prostate cancer [42]. This evidence concerns the gene TPD52 and Familial prostate cancer.