TPD52 and hereditary clear cell renal cell carcinoma: However, high-level TPD52 staining was shown to be significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma [60], and TPD52 expression was significantly decreased in the hepatocarcinoma cell carcinoma (HCC) tissues and renal cell carcinoma (RCC) cells and was associated with improved OS and disease-free survival (DFS) in HCC patients [61,62].