The multivariable analysis identified the cause of renal failure (OR 0.44; 95% CI 0.19–0.99, P< 0.05), anti-BKPyV IgG (OR 4.01; 95% CI 1.54–10.46, P<0.01), and percent of T-cells which are CD8+ (OR 1.04; 95% CI 1.00–1.07, P = 0.05) and CD4+ (OR 0.95; 95% CI 0.92–0.98, P<0.01) as associated with viral reactivation. The gene discussed is CD8A; the disease is kidney failure.