Of note, transfection of BRCA1 shRNAs into FOXP3 Tet-off MCF7 cells reduced the induction of miR-155 by FOXP3 (Figure 3B), indicating the existence of a transcriptional mediator, BRCA1, between FOXP3 and miR-155 in human breast cancer cells. The gene discussed is BRCA1; the disease is breast carcinoma.