Multivariate analysis identified that CEA > 10 U/mL (HR: 1.794; 95% CI: 1.166–2.761), CA19-9 > 39 U/mL (1.641; 1.218–2.213), tumor diameter > 5 cm (1.445; 1.080–1.933), multiple tumors (1.464; 1.089–1.968), vascular invasion (1.944; 1.317–2.868), nodal metastasis (2.034; 1.376–3.008) and local extrahepatic invasion (1.933; 1.159–3.223) were associated with recurrence (Table 2). This evidence concerns the gene CEACAM5 and neoplasm.