Multivariate analysis demonstrated that carcinoembryonic antigen (CEA) > 10 U/mL (hazard ratio [HR]: 1.812; 95% confidence interval [CI]: 1.180–2.784), carbohydrate antigen 19-9 (CA19-9) > 39 U/mL (1.711; 1.261–2.322), tumor diameter > 5 cm (1.369; 1.011–1.853), multiple tumors (1.614; 1.183–2.203), vascular invasion (1.847; 1.246–2.739), nodal metastasis (2.302; 1.552–3.413) and local extrahepatic invasion (2.284; 1.349–3.869) were significantly associated with ICC-related deaths (Table 2). The gene discussed is CEACAM5; the disease is intrahepatic cholangiocarcinoma.