This study specifically investigated the patients with ICC who have survived more than 10 years after surgery, and found that these patients experienced recurrence later and were more likely to have smaller and solitary tumor without any nodal metastasis or local extrahepatic invasion, as well as lower CEA, CA19-9 and ALP levels and less operative blood loss. The gene discussed is CEACAM5; the disease is intrahepatic cholangiocarcinoma.