DDB2 and melanoma: Several mechanisms protect melanoma cells from cisplatin-induced cell death, either (i) by activating DNA-repair systems such as the p53-dependent upregulation of the nucleotide excision repair (NER) genes Xeroderma pigmentosum complementation group C (XPC) and damaged DNA-binding protein 2 (DDB2) [7] or (ii) by pH-dependent sequestration and extrusion of cisplatin through exosomes [8].