FOXP3 and rheumatoid arthritis: However, the expression levels of Foxp3 and SOCS3 mRNA can be upregulated after the WJHL dose groups are given pharmacological intervention compared with the CIA group, indicating that WJHL could upregulate the expression levels of negative feedback modulator SOCS3 mRNA and regulatory T cells (Treg)-specific transcription factor Foxp3 mRNA, which can significantly change RA symptoms based on the increase or decrease in dose.