While an increase in the level of blood S100 proteins in response to inflammation has been widely documented and positively correlate with cardiovascular risk, diabetes and proteinuria [37, 38], the opposite was found here for exosomal fractions in hypertensive patients with incipient or no albuminuria, which showed decreased levels of S100A8 and S100A9. This evidence concerns the gene S100A8 and diabetes mellitus.