We evaluated a sub-set of representative proteins significantly responding to de novo albuminuria, myeloperoxidase (MPO), olfactomedin-4 (OLFM4) and antithrombin-III (AT3), using a different analytical technique (SRM-LC-MS/MS) in an independent cohort of 40 non-diabetic hypertensive patients under chronic suppression of RAS and in 14 healthy subjects. The gene discussed is OLFM4; the disease is hypertensive disorder.