We have now shown that rs12229654 at 12q24.1 was significantly associated with both systolic and diastolic BP as well as with hypertension and that rs671 of ALDH2, rs11066015 of ACAD10, rs2074356 and rs11066280 of HECTD4, and rs3782886 of BRAP were significantly associated with both systolic and diastolic BP. This evidence concerns the gene HECTD4 and hypertensive disorder.