Indeed, NF-κB can be activated in MM cells by diverse bone marrow-derived cytokines and growth factors (e.g., BAFF/BAFF-R [74], APRIL/BCMA [75], CD40L/CD40 [76]) and by direct physical contact between MM cells and stromal cells [77]. The gene discussed is TNFRSF13C; the disease is Miyoshi myopathy.