Finally, genetic gains/amplifications of the BIRC2 and BIRC3 loci, encoding the cIAP1 and cIAP2 E3 ubiquitin ligases, respectively, were detected in as many as 16% of ABC-DLBCL, but rarely in GCB-DLBCL [45]. Here, BIRC3 is linked to aneurysmal bone cyst.