Some DLBCL patient biopsies show a deregulation of the glycolytic enzyme GAPDH that resulted in the activation of a NF-κB/HIF-1α (Hypoxia inducible factor 1) axis that could support lymphoma growth and vascularization through the induction of VEGFR [48]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.