NFKB1 and acute lymphoblastic leukemia: The mechanism of Notch-induced NF-κB activation in T-ALL involves Hes1, which transcriptionally represses CYLD (cylindromatosis), a deubiquitinase which down-regulates NF-κB signaling by removing the activator K63 ubiquitin chains from different elements of the NF-κB signalosome [23].