Finally, recurrent deletions of the chromosomal region 6q23 involving TNFAIP3/A20 have been found in HL cell lines and HRS cells, as well as inactivating TNFAIP3 somatic mutations in several HL cell lines and in about 45% of classical Epstein-Barr virus (EBV)-negative HL cases [59]. This evidence concerns the gene TNFAIP3 and Hodgkins lymphoma.