As a protein complex that controls the transcription of DNA, cytokine production and cell survival, NF-κB is activated in response to external stimuli including infection, inflammation, radiation, and oxidative stress resulting in upregulation of a number of downstream stress response genes such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNFα), and intracellular adhesion molecule (ICAM) [13,14,15]. Here, NOS2 is linked to infection.