In the colorectal and breast cancer models, the lncRNA ANCR suppresses invasion and migration properties by down-regulation of EZH2 via ANCR-mediated CDK1-EZH2 interaction and phosphorylation at Thr 345 and Thr 487 on EZH2, facilitating its ubiquitination and degradation [66,67]. Here, EZH2 is linked to breast cancer.