Loss of PRC2-mediated histone H3K27me3 activates hypoxia-inducible transcription factors (HIF)-driven expression of chemokine (C-X-C motif) receptor 4 (CXCR4), leading to metastasis of clear cell renal carcinoma (ccRCC) cells [73]. The gene discussed is CXCR4; the disease is nonpapillary renal cell carcinoma.