The phosphorylated EZH2 act as a co-activator for critical transcription factors, such as androgen receptor (AR) in prostate cancer cells [24], signal transducer and activator of transcription 3 (STAT3) in glioblastoma stem-like cells [25], and RelA/RelB in estrogen receptors (ER)-negative basal-like breast cancer cells [26], to promote the expression of the target genes of AR, STAT3, and nuclear factor-kappa B (NF-κB), respectively. The gene discussed is ESR1; the disease is prostate carcinoma.