HMOX1 and Alzheimer disease: Orientin, a flavone, was shown to activate Nrf2, increase HO-1 and ARE signaling, reduce the levels of ROS, 3-NT, 4HNE, and 8-OHdG, and attenuate Aβ1-42 peptide-induced mitochondrial dysfunction and apoptotic pathway and cognitive defects in AD mice [203].