LHB and major depressive disorder: Moreover, dysfunctions of the LHb are associated with several devastating mental disorders, including depression, schizophrenia, and drug withdrawal symptoms (Morris et al., 1999; Shumake et al., 2003; Shepard et al., 2006; Yang et al., 2008; Salas et al., 2009; Li et al., 2011, Li et al., 2013; Tost et al., 2015).