To demonstrate the generality of the Seldeg approach, antibodies specific for two antigens were targeted (Fig. 1a): first, the extracellular domain (ECD) of myelin oligodendrocyte glycoprotein (MOG-Seldeg), which is recognized by autoreactive antibodies in both animal models of multiple sclerosis and multiple sclerosis in humans11, 12, 13. Here, MOG is linked to multiple sclerosis.