AKT1 and breast cancer: We also found same pathway enrichment for other breast cancer mutations: ubiquitination genes for MAP3K1mut (P value=2.3 × 10−6), growth factor signalling (specifically neurotrophin, including AKT signalling) for PIK3CAmut (P value=0.0002), ‘response to endogeneous stimuli' for GATA3mut (P value=0.02), and adherens junction genes for CDH1mut (P value=0.02).