Interestingly, MiSL candidates of BRCA1 mutation in breast cancer were significantly enriched for DNA repair genes, including XRCC6 and FANCC, with P value=0.006 (hypergeometric test, Supplementary Fig. 3a), consistent with the clinically established SL interaction between inhibition of DNA repair and BRCA1mut1, 33. This evidence concerns the gene XRCC6 and breast cancer.