We compared the SL partners found by DAISY with those identified in our shRNA screen for mutant IDH1 in AML (Supplementary Fig. 6a) and found that there was no statistically significant association between the two lists (Supplementary Fig. 6b,c), indicating that DAISY's predictions are not enriched for IDH1mut SL partners in AML. This evidence concerns the gene IDH1 and acute myeloid leukemia.