In a first step, we evaluated available exome data of 46 melanoma cell lines15, established from metastases of different patients in our laboratory, for aberrations in IFNGR1, IFNGR2, JAK1, JAK2, STAT1 and IRF1. Mutations in JAK1 (n=3), JAK2 (n=1) and STAT1 (n=1) were detected in 5 out of the 46 cell lines (Table 1). Here, IRF1 is linked to melanoma.