However, some subunits specific to R2TP/PFDL, namely URI1 and UXT, were shown to be amplified, overexpressed or otherwise linked to tumour progression in prostate, ovarian, cervical and endometrial cancer, hepatocellular carcinoma and multiple myeloma69, 70, 71, 72, 73, 74, 75, 76. The gene discussed is URI1; the disease is hepatocellular carcinoma.