Human TTBK kinases have been associated with neurodegeneration, where TTBK1 is thought to phosphorylate Tau protein and promote the progression of Alzheimer's disease (Sato et al., 2006) and TTBK2 has been linked to another Tau‐related disease, spinocerebellar ataxia 11 (SCA11) (Ikezu & Ikezu, 2014). Here, TTBK2 is linked to early-onset autosomal dominant Alzheimer disease.