Both, Wang et al. and Costa‐Pereira et al. provide evidence that STAT3 acts as a negative regulator either of the type I IFN or IL‐6 response, as viral infection and/or cytokine activation of STAT3‐deficient MEF resulted in enhanced/prolonged STAT1 phosphorylation and ISG expression. The gene discussed is STAT1; the disease is viral infectious disease.