Our data from cohort 1 analysed by suicide status is consistent with the earlier finding of lower PLCB1 protein in membrane and cytosol fractions from BA8/9 in adolescent suicide regardless of history of mental illness,15, 32 however this is not supported by our findings in cohort 2 of no difference in suicide completers with MDD, BD or no history of mental illness. Here, PLCB1 is linked to major depressive disorder.