However, desynchronization of ultradian and circadian rhythms by excessive dopaminergic tone can lead to interference in rhythmic behaviors.77 Therefore, disruptions of the CNS dopamine and circadian systems may change reward systems in the NAc, alter satiety set points, and contribute to overeating and obesity.73, 75, 78 Overall, this evidence suggests that CNS dopamine, D2R and D3R play critical roles in mediating rhythmic feeding behaviors and satiety, and that the loss of circadian regulation may result in clinically relevant disturbances in maintaining weight control. The gene discussed is DRD2; the disease is obesity due to melanocortin 4 receptor deficiency.