Prior studies suggested that interleukins may be associated with schizophrenia pathology.60 The NF-kB signaling pathway may also have an important role because NF-kB molecule has key role in immune response regulation and is associated with RA pathology; it has also been implicated in synaptic plasticity and memory, which are commonly altered in schizophrenia patients.61, 62 The PPIs, including novel PPIs that we predicted, highlight how the RA and SZ genes connect to pathways that are of interest in the biology of both the diseases (examples shown in Table 2). This evidence concerns the gene NFKB1 and schizophrenia.