To target the GluN1 ablation into GABA neurons in development, we crossed the floxed-GluN1 mice to a Dlx5/6-cre line, in which Cre recombination occurs in migrating forebrain GABA neurons of the embryonic brain.117 However, we found that no homozygously-floxed mutant mice survived, suggesting that NMDAR function in migrating GABA neurons is fundamental for brain development and survival, but beyond the schizophrenia pathophysiology (Nakazawa, data not shown). This evidence concerns the gene GRIN1 and schizophrenia.