28 Importantly, GluN2D-containing NMDAs are selectively distributed in PV-positive and/or somatostatin-positive interneurons of the cortex and hippocampus in adulthood.110,111,27 Therefore, a specific deficit in NMDAR signaling in fast-spiking PV neurons may explain certain aspects of NMDAR hypofunction-mediated schizophrenia-related phenotypes. The gene discussed is GRIN2D; the disease is schizophrenia.