GRIN1 and schizophrenia: Furthermore, corpus callosum development is rather accelerated in both the mutants and GluN1 haploinsufficiency (+/-) mice compared to the wild type mice.74 In contrast, the volume of central corpus callosum is known to be significantly decreased in schizophrenia,75 with effects more detectable in first-episode than chronic schizophrenia.76 In this context, global NMDAR hypofunction in the late gestation period is unlikely to take place in schizophrenia pathogenesis.