MSN and malaria: Moreover, we reasoned that moesin may play a role in the immune response to Plasmodium infection via its ability to interact with Plasmodium GPI as well as in malaria pathology due to its ability to modulate immunological synapse and endothelial paracellular gap formation (Itoh et al., 2002; Koss et al., 2006; Parameswaran and Gupta, 2013).