In contrast, naproxen, the non-selective NSAID with less anti-COX-2 activity, attenuated the IS reducing effect of atorvastatin, but compared with controls, co-administration of atorvastatin and naproxen still lead to significantly reduced IS; 4) Although, overall numbers of premature ventricular contraction (PVCs) and ventricular tachycardia (VT) episodes were lower in the atorvastatin group, atorvastatin failed to offer significant protection from arrhythmias. The gene discussed is PTGS2; the disease is cardiac arrhythmia.