PTGS2 and cardiac arrhythmia: Aims: 1) To determine, if naproxen and diclofenac, two widely used non-selective NSAIDs with different anti-COX-2 activity [21], interfere with atorvastatin-mediated protection of myocardium from IR injury; 2) to determine, if there are significant differences in the level of attenuation of IS-limiting effect of atorvastatin between the two drugs; 3) to determine the effect of the administered medicine on incidence and severity of IR-induced arrhythmias during the protocol.