PTGS2 and Arrhythmia: In contrast, naproxen, the non-selective NSAID with less anti-COX-2 activity, attenuated the IS reducing effect of atorvastatin, but compared with controls, co-administration of atorvastatin and naproxen still lead to significantly reduced IS; 4) Although, overall numbers of premature ventricular contraction (PVCs) and ventricular tachycardia (VT) episodes were lower in the atorvastatin group, atorvastatin failed to offer significant protection from arrhythmias.