Repeated measures ANOVA was used to analyze the interaction between the subgroup of postoperative hypokalemia and the measurement time points, the result showed that the interaction between postoperative hypokalemia and time is not statistically significant (P = 0.321), and a statistically significant correlation and that postoperative hypokalemia was predominant among patients with ACTH-pituitary adenomas (P = 0.033). This evidence concerns the gene POMC and Hypokalemia.