To assess the role of α7nAChR on CNS disorders, we treated EAE mice with α7nAChR agonist PNU282987 in the doses of 0.03 and 0.1 mg/kg body weight, respectively, from days 3 postimmunization (PI) till the end of study, and found that PNU282987 at the dose of 0.1 mg/kg body weight could effectively reduce the peak severity and cumulative clinical score of EAE while only slight decreases in the peak severity and cumulative clinical score were detected at the dose of 0.03 mg/kg body weight (Figure 1A). This evidence concerns the gene CHRNA7 and central nervous system disorder.