CHRNA7 and myocardial ischemia: Our previous works have demonstrated that activating α7nAChR plays a protective role in several kinds of cardiovascular diseases including ischemic stroke, hypertension, and myocardial ischemia via the “cholinergic anti-inflammatory pathway.” It has been demonstrated previously that activating α7nAChR alleviates EAE through the inhibition of inflammatory reaction (14–16).