Moreover, filaggrin is a key protein in the function of the epidermic epithelial barrier, and Cabanillas and Novak (52) have shown that the development of peanut allergy in children that carry one or more mutations in the filaggrin genes is provoked even when they are exposed to very small quantities of allergen, a risk that increased with higher dose exposure. The gene discussed is FLG; the disease is peanut allergic reaction.