APP and Alzheimer disease: Other genes, besides being implicated in AD, are suspected to be linked with age-related cognitive decline in healthy aging, e.g., APP and TOMM40 (Caselli et al., 2012; Jonsson et al., 2012; Davies et al., 2015; Payton et al., 2016) also may be regulated by CREB (Ge et al., 2004; Zhang et al., 2005; Tanis et al., 2008; Rodriguez-Tornos et al., 2013).