The importance of these chaperones was demonstrated in studies showing that the hereditary mutations in HSPB1/Hsp27 and the associated reduced ability to maintain proteostasis gave rise to a great number of neurodegenerative disorders, including Charcot-Marie-Tooth disease and ALS (Echaniz-Laguna et al., 2017). Here, HSPB1 is linked to amyotrophic lateral sclerosis.