SNCA and Alzheimer disease: Hsp70 with its DnaJ-like aide have been shown to inhibit the growth of aggregates of huntingtin and the other proteins with long polyglutamine repeats (Labbadia et al., 2012), α-synuclein in a model of PD (Auluck et al., 2002), tau in AD (Zhang et al., 2008), and two key pathogens in ALS, SOD1, and TDP-43 (Koyama et al., 2006; Udan-Johns et al., 2014).