AQP1 and Alzheimer disease: As is the case with other diseases associated with misfolded proteins, analysis of AD brains and AD animal models revealed increased levels of Hsps and their co-chaperones, including Hsp27 (Renkawek et al., 1994), Hsp70 (Perez et al., 1991), and STI1 (Ostapchenko et al., 2013).