HSP90AB1 and neurodegenerative disease: The abundance of exposed hydrophobic stretches in proteins prone to self-association in neurodegenerative diseases draws parallel to proteins in early stages of folding, which indicates a potential role of the Hsp70/Hsp90 machinery in modulating pathogenic aggregate formation (Muchowski and Wacker, 2005; Hartl and Hayer-Hartl, 2009).