MAPT and tauopathy: In addition, chaperone-mediated autophagy (CMA) has been shown to protect against accumulation of tau, α-synuclein, and polyQ-huntingtin (Htt) in models of tauopathy, PD, and HD, respectively (Wang Y. et al., 2009; Qi et al., 2012; Xilouri et al., 2013).