Tau is abnormally phosphorylated in AD due to increased activity of GSK-3 and other tau kinases (Alvarez et al., 1999; Avila et al., 2010; Tremblay et al., 2010; Cavallini et al., 2013), likely as a result of initial Aβ toxicity (Tamagno et al., 2003; Ryan et al., 2009; Hernandez et al., 2010). This evidence concerns the gene MAPT and Alzheimer disease.